This paper presents an educational video game developed to teach students about the human immune system. The work is grounded in long-standing principles of educational video game design, and considers an earlier commercial game with a similar theme.

The background section on the immune system is completely inaccessible to a reader who does not have a solid background in this area. The background on software design and the development process is sketchy. In the conclusion, the authors analyze their game in terms of principles of educational video game design. This section is interesting--it should have been in the body of the paper rather than the conclusion. Finally, there is no empirical validation of the game design, even though this sort of endeavor cries out for empirical validation.

Having said all that, I acknowledge that this is a proceedings paper, which means that it is a work in progress. Hopefully, the work will eventually make its way into a journal and some of the shortcomings will be corrected. In short, the paper is promising but needs work.