S. Ramesh has been with with General Motors Global R&D for the last 10 years, where he currently holds the position of Technical Fellow and Thrust Area Lead for model-based embedded software. At General Motors, he is responsible for providing technical leadership for research and development in several areas related to electronics, control & software processes, methods, and tools. He has been an active industrial member of the Network for the Engineering of Complex Software-Intensive Systems for Automotive Systems (NECSIS), sponsored by the Automotive Partnership Canada. NECSIS is a research program focusing on making model-driven engineering into a mature industrial engineering methodology. As a member of NECSIS, Ramesh is responsible for monitoring and providing direction, and to facilitate interactions among the partners involved in NECSIS and GM Engineering.

Earlier, Ramesh was on the faculty of the Department of Computer Science & Engineering at the Indian Institute of Technology Bombay (IITB), India, for more than 15 years. At IITB, he played a major role in setting up a National Centre for Formal Design and Verification of Embedded Software.

His areas of research are rigorous software engineering, embedded systems, and real-time systems. He has published more than 100 papers in international journals and conferences. He has been on the editorial boards of the International Journal on Real-Time Systems and the Eurasip Journal on Embedded Systems and the IEEE Journal on Embedded System Letters.