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The formation of three-dimensional biological structures: computer uses and future needs
Levinthal C.  Computer culture: the scientific, intellectual, and social impact of the computer (, New York,1801984.Type:Proceedings
Date Reviewed: Sep 1 1986

Levinthal describes, in a very clear and elementary way, how computers have aided in modeling the structure of biological molecules and macromolecules. He gives the reader an idea of the complexity of the task without resorting to technical obfuscation. The paper seems like an upbeat keynote address to his colleagues in theoretical neurobiology.

He uses two examples from his own work to explain the processes used in his research: molecular model building and the construction of nerve nets in growing organisms. None of the material presented was either too complex for a general scientific audience or too boring for his colleagues to read.

The complexity of the simultaneous processes which must be modeled is made clear in his description of the attempt to model protein assembly and folding in a protein like DNA. He reports the beginnings of success in the modeling of a small peptide which can insert itself in a phospholipid membrane.

The work reported on the growth and development of nerve nets is described in general terms. The three dimensional reconstruction of nerve movement over time has required development of new techniques for precise alignment of serial sections.

Levinthal concludes with thoughts about future research in developmental neurobiology. Much more powerful computers will lead to advances in understanding of biological processes. Better understanding about the processes will lead to improved models. The technology that has helped in current understanding will advance. Special purpose computers with multiple parallel processors, parallel VLSI architecture, and other advances will help free neurobiologists from limits imposed by currently available computational tools.

Reviewer:  R. W. Lambert Review #: CR110379
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Biology And Genetics (J.3 ... )
 
 
Applications (I.6.3 )
 
 
Miscellaneous (I.3.m )
 
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