Along with the successful use of intelligent agents in the healthcare domain, researchers have been motivated to study the application of software engineering knowledge in this field.

Over 200 papers, together with 15 core publications, were selected by the authors of this paper as a comparative study. Various parameters, for example, agent types and their values, are identified and addressed during the study. Both simulated and implemented intelligent-based systems are comparatively analyzed, such as multiagent systems (MAS) for optimal resource scheduling, decision support systems as medical assistive tools, simulated environments for optimization for data retrieval capabilities, remote and self-care systems with different types of agents, and multifunction MAS like agent hospitals. Concerns like security, trust, data encryption, access control, and so on are also discussed along with the analysis. The authors provide discussions on the limitations of MAS and recommendations.

This paper provides an intensive study on the research and application of intelligent agents in the healthcare domain and is recommended for those who are interested in the field.